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Zhu Y, Hu Y, Yang C, Huang S, Wen J, Huang W, et al

PPG neurons in the nucleus tractus solitarii (NTS) are widely assumed to link the peripheral and central GLP-1 systems in a unified gutbrain satiation circuit

Use patterns, symptoms, and medication context to guide the discussion with your care team

Once you stop taking semaglutide, your GLP-1 receptor signaling returns to baseline within days to weeks, allowing appetite hormones like ghrelin to rise again

In addition, neurotransmitter-mediated interactions, particularly GABA-mediated, are implicated in appetite stimulation for carbohydrates and energy expenditure reduction (Jallon and Picard 2001)