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Priority Health similarly requires step therapy but accepts documented contraindications to first-line agents as an exception pathway

QW: Formal Analysis, Methodology, Writing review and editing

In the phase 2 obesity trial, nausea occurred in 63% of subjects at the 12 mg dose versus 20% on placebo during the titration phase, but fell to below 15% at steady state [5]

J Manag Care Spec Pharm 2017;23:44652.ArticlePubMedPMC 69

Their heavily glycosylated structure and stable hydrolase complexes protect lysosomes from degradation by acid hydrolases, making the integrity and degradative capacity of lysosomes largely dependent on LAMP-1 and LAMP-2