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One theory for both effects is that rapid glucose reduction might initially worsen the health of blood vessels in the eyes
Let-7a targets IGF-2, which is oncogenic in NSCLC tissue [25]
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The side effects most frequently reported in the clinical literature and in real-world use are typically mild and dose-related: Injection site reaction: Brief redness, mild soreness, or small bruising at the injection site
Consequently, many GSH-responsive nanoplatforms are designed either to deplete GSH by targeting these pathways or to exploit high GSH levels as triggers for selective drug release
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