At the molecular level, the prolactin gene contains two distinct promoter regions: the proximal promoter drives basal and regulates prolactin transcription, predominantly in pituitary lactotrophs, whereas the distal promoter is implicated in tissue-specific extrapituitary prolactin expression ( 2 receptors on lactotrophs, leading to the suppression of prolactin gene transcription and hormone secretion ( In addition to dopaminergic inhibition, prolactin secretion is modulated by a diverse array of hypothalamic factors including vasoactive intestinal peptides, serotonin, histamine, oxytocin, estrogen, thyrotropin-releasing hormone, dopamine receptor antagonists, and epidermal growth factor ( 2.2 Target site The biological effects of prolactin are mediated by the prolactin receptor (PRLR) and its canonical downstream JAK2/STAT5 signaling pathway
In general, the activation of the inflammasome requires two independent signals
Hsdb 3339 236
[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Wang M-X, Yin Q, Xu X
Effect of host derived glutathione on disease susceptibility of host cells to Frog Virus 3 To explore whether changes in host cell glutathione cause a generalised effect on disease susceptibility, the above experiment was repeated with a ranavirus as an alternative amphibian pathogen
