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Actively identifying patients who are susceptible to irAEs could help monitor them, provide appropriate care, and prevent complications from potentially life-threatening irAEs while ensuring optimal cancer treatment response

Fifth-generation CAR structures integrate a truncated cytoplasmic IL-2 receptor -chain (IL-2R) domain and a STAT3 or STAT5-binding moiety, enhancing the second-generation design

However, the specific inflammatory profiles and cytokine levels may vary between the TMJ and the knee, leading to distinct outcomes in terms of ferroptosis-mediated chondrocyte death and cartilage damage

Theranostics 4(2):215228 Humphreys BD, Forman JP, Zandi-Nejad K, Bazari H, Seifter J, Magee CC (2005) Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital