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Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice

J Braz Chem Soc 23(11):20032010 Orian L, Mauri P, Roveri A, Toppo S, Benazzi L, Bosello-Travain V, De Palma A, Maiorino M, Miotto G, Zaccarin M, Polimeno A (2015) Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study

Proc Natl Acad Sci USA 2011;108:87738

The resulting cells displayed oxidative imbalance, reduced cellular and mitochondrial respiration rates, lower ATPase transcript levels, decreased mitochondrial membrane potential, and impaired mitochondrial complex activity