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Figure 4: Simplied structure of Semaglutide After modication, the guanidino group on the side chain of Arginine (Arg) at position 34, the carbonyl group on the alpha-carbon, and the carboxyl group on the side chain of Glutamic acid (Glu) at position 27 achieve the specic acylation of Lysine (Lys) at position 26 through non-covalent interactions with water molecules

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