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The agitation introduces air bubbles that create foam, and the foam-liquid interfaces generate shear stress that denatures the protein

Visible-to-NIR-light activated release: from small molecules to nanomaterials

Dihexas trajectoryfrom claims of being seven orders of magnitude more potent than BDNF in rodents to a failed Phase 2/3 trial and retracted foundational researchexemplifies this valley of death. This pattern demands particular caution when extrapolating from compelling animal data to expectations for human cognitive benefit

Preclinical murine tumor models: a structural and functional perspective