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Shifting to every-other-day administration during weeks 46 reduces cumulative receptor occupancy and slows further desensitization while still maintaining therapeutic plasma IGF-1 LR3 levels, extending the effective anabolic window by 12 weeks compared to continuous daily dosing that plateaus completely by week 5

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10.1016/J.PHRS.2021.106039 11 BoseS.ZhangC.LeA

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