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Clinical Studies The main methods of administration seen in animal studies are topical creams, injections, and oral consumption, as follows: In a 2001 study by Mikus et al

Weight regain is commonly observed after discontinuation

For example, in the STEP 4 study , people who switched to placebo after 20 weeks gained an average of 6.8% of their body weight back, while those who continued semaglutide lost additional weight