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Then layer in the technical barriers to generic entry (bioequivalence complexity, limited generic manufacturer capability, FDA product-specific guidance requirements) to assess the probability and magnitude of price erosion for each year of the patent window

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attenuates in most patients as gastric adaptation occurs First-line management: Dietary sulfur load reduction, meal timing relative to injection day, and small-portion eating When to escalate: Persistent belching paired with regurgitation, significant dysphagia, or weight loss beyond expected therapeutic loss warrants GI evaluation When to discontinue: Sulfur burps alone are rarely grounds for stopping

Your clinician may also recommend probiotic supplements containing Lactobacillus and Bifidobacterium species to help restore healthy colonic bacteria disrupted by rapid gastric emptying

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