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ATTAIN-2 (NCT05872620) This trial evaluated orforglipron in adults with obesity or overweight who also had type 2 diabetes, a critically important subpopulation given the high co-prevalence of these conditions

On the basis of these findings, a clinical study program was started to investigate the efficacy and safety of tirzepatide in the treatment of obesity and obesity management

In this context, the Barbie drug is not actually about tanning

GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts

From a landmark 2011 double-blind study published in the Journal of Physiology: [Carnitine supplementation] results in muscle glycogen sparing during low intensity exercise (consistent with an increase in lipid utilisation) Furthermore, these changes were associated with an improvement in exercise performance . *This second mechanism is why L-carnitine supplementation is particularly effective at fueling weight loss when paired with a low-carb diet such as keto