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Tasci I, Naharci MI, Bozoglu E, Safer U, Aydogdu A, Yilmaz BF, et al

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Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

Graphical abstract Access this article Similar content being viewed by others References Manoj M, Yuan A (2020) A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review