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All these data are shown in Figures 2, 5

Dose Titration Schedule Clinical trials established that starting with lower doses and gradually increasing reduces gastrointestinal side effects while maintaining long-term efficacy

Hydrate aggressively now, not after dehydration causes problems

Beyond the protein-based methodologies used to characterise glicentin, GRPP and oxyntomodulin, the increased capability to sequence genes at the time led to the first sequence of mammalian preproglucagon (15)