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Similar rhythmic, clock-dependent CI respiration was observed in inguinal WAT (iWAT) (Extended Data Fig

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The microdosing schedule may be prescribed as follows: Weeks 14: 1.0 mg once weekly Weeks 58: 1.5 mg once weekly Weeks 912: 2.0 mg once weekly Week 13 and beyond: Transition to the standard 2.5 mg dose, then proceed with the standard escalation plan