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performed on 40 randomized clinical trials including T2DM patients showed that GLP1-RAs reduce oxidative stress and the levels of inflammatory markers including CRP [50]

In 2020, it became the only diabetic drug to be approved for reducing or preventing the risk of major cardiovascular events (MACE) in patients with type 2 diabetes

These drugs are FDA-approved for type 2 diabetes and obesity, but growing evidence supports their use for rheumatoid arthritis, psoriatic arthritis, lupus, osteoarthritis, and metabolic/autoimmune diseases. Who should not take GLP-1 medications

Participants received once-weekly injections of retatrutide at either the 9mg or 12mg dose, or a placebo, over 68 weeks

Patients who have tried lifestyle changes and want evidence-based pharmacologic help