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Gel: 0.75 mg/day (one pump), titrated to symptom response and estradiol level (target 40-100 pg/mL in postmenopause, 50-150 pg/mL in perimenopause)

Vitamin D supplementation benefits most Canadians given limited sun exposure, particularly relevant for those losing fat tissue where vitamin D is stored

Which drug is considered more effective for weight loss is Wegovy due to its higher 2.4mg dosing specifically designed for weight management, achieving 10-15% average weight loss compared to lower Ozempic doses

Administration routes vary: subcutaneous injections for systemic peptides, oral forms when bioavailability allows, and topical or intra-vaginal formulations when local delivery reduces systemic exposure

Renal Impairment: Although rare, Semaglutide could affect kidney function