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GLP-1 receptors are activated by mimicking the endogenous GLP-1 to enhance insulin secretion and inhibit glucagon secretion in a glucose-dependent manner, as well as delay gastric emptying and reduce food intake through the suppression of appetite, thereby reducing blood sugar

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Indications: FDA approved: Type II diabetes - monotherapy or combination therapy Can be combined as adjunct therapy with other hypoglycemics including metformin, thiazolidinediones, or insulin regimens (Dungan & DeSantis 2015) Because it does not work when your blood sugar is low, it is unlikely to produce dangerous levels of hypoglycemia has been observed in clinical trials (in contrast to GLP-1 incretin mimetics, such as exenatide, which produce moderate weight loss)

Lever M, George PM, Dellow WJ, Scott RS, Chambers ST