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TB-500 distributes broadly through connective tissue, muscles, and joints throughout the body, which makes it particularly useful for patients dealing with multiple injury sites, diffuse connective tissue inflammation, or slower-healing chronic conditions that a localized peptide cannot fully address

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Inducers of CYP3A4 The concomitant use of hydrocodone bitartrate and acetaminophen tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of hydrocodone (see CLINICAL PHARMACOLOGY), resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to hydrocodone (see WARNINGS)

The peptide works systemically even when injected locally