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Some studies have examined a possible link between isotretinoin and mood changes, and certain antidepressants may interact with the liver enzymes that process isotretinoin
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Chang, Y., Huang, R., Zhai, Y., Huang, L., Feng, Y., Wang, D., Chai, R., Zhang, W., & Hu, H
10.1210/en.2008-0747 169 StengelA.TachY
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