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However, our acceptances to both experimental and control group due to the paucity of available data, a lack of information on which disease phenotype of each participants belonged to and no uniformity of lifestyle intervention, GLP1RAs type or treatment duration, led to a moderate to high heterogeneity in some main outcomes

doi:10.1016/j.iac.2018.04.003 Sperr WR, Jordan JH, Fiegl M, et al

P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

Last Reviewed: Q4 2025 Originally developed to treat Type 2 Diabetes, GLP-1s have since gained FDA approval for a variety of diseases, with new indications continually emerging

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