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Preclinical research suggests potential direct cardioprotective mechanisms

But they said that the bulk of the peer-reviewed research to date shows that few people can maintain all of their weight loss after coming off GLP-1 medications

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Tirzepatide (Mounjaro, Zepbound) doesn't

The resultant decrease in FFA availability reduces its hepatic uptake and fatty acid oxidation, changing the disposal of substrates that are mostly used for gluconeogenesis (Galgani et al., 2008)