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Patients should maintain realistic expectations about skin changes during significant weight loss

These patterns may indicate reduced medication potency rather than disease progression or diet changes

As such, losing this fat can lead to increased foot pain, especially if youve been standing or walking for long periods of time

Last updated: January 2026 Reviewed as clinical guidance and access criteria evolve Disclaimer The information on this page is for educational and informational purposes only and is not intended as medical advice

In the case of the developed IGF-1 MSIA-SRM, the use of the MSIA tips in comparison to beads translated into a 10-fold lower limit of detection and a 20-fold LLOQ for an extraction method requiring less than 30 minutes