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Epidemiology 2008;19:55-62
For example, alternating between 7.5 mg and 10 mg weekly can provide an effective average dose of approximately 8.75 mg
Initial studies should focus on determining safe dosing parameters, understanding their pharmacokinetics, and assessing potential interactions
Ghosh, S., et al
Its cardiovascular safety in patients with cardiovascular disease or high cardiovascular risk was demonstrated in the aforementioned PIONEER-6 study.62 In the PIONEER 5 study, in patients with CKD stage 3, it was evaluated the efficacy and safety of a 14 mg dose, resulting superior to placebo in terms of reduction of HbA1c (-0.8% vs
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