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The intracellular portion of these nano-sensors, has evolved in humans in a complex hub that triggers multiple molecular cascades that results in short-term and long-term modifications of the target cell and even the whole-body metabolism
Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F et al (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
The costs of implementation are modest compared to the current economic burden of delayed diagnosis, which includes excess healthcare utilization, productivity losses, and reduced quality of life
10.1126/sciadv.1701028 21 Serrano-LotinaA.PortelaR.BaezaP.Alcolea-RodriguezV.VillarroelM.vilaP
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