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In a randomized controlled trial assessing the effects of butyrate in obese children, there was a consistent response which showed a significant reduction of bodyweight and waist circumference compared to placebo [4]. Per-protocol analysis in the butryate group revealed a decrease in BMI of 2.26 units and a reduction in waist circumference by 5.07cm in 6 months [4]
As only one patient completed the study in Group B, the two groups were pooled for safety analyses
Furthermore, it is important to take into account breastfeeding as there may be a chance that the drug passes into breast milk and affects the newborn
The three approved areas for subcutaneous injection are the abdomen (at least 2 inches from the belly button), the front of the thigh (middle third), or the back of the upper arm
Even then, NHS access may be further restricted by NICE technology appraisal guidance
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