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If this dilation of lymphatic vessels is consistent with lymphostatic decompensation (failure of lymphatic vessel function) in lipedema as the authors suggest, then salt should be found in the skin of women with lipedema as lymphatic vessels regulate Na+, Cl and water in the skin, where reduced lymphatic vessel numbers are paralleled by increased blood pressure (82)
It is also, notably, the same property that makes systemic dosing worth scrutinizing: a molecule whose defining feature is carrying copper is a molecule whose systemic use has to be evaluated in light of how the body already manages copper
2009.PMID Ahnfelt-Rnne I, Nowak J, Olsen UB
Funding This study was supported by grants from the National Natural Science Foundation of China (82302925, 82272702), Natural Science Foundation of Zhejiang Province (LQ23H160012, LZ23H160001, LTGY23H080005), the project of Science and Technology Plan of Traditional Chinese Medicine of Zhejiang Province (2024ZL1010), Wenzhou Science and Technology Bureau of China (ZY2023021), and in part supported by the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A)