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ARA is specifically released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), which is translocated to the membranes in a cytosolic calciumdependent manner after its phosphorylation on Ser505 by MAPK

Adults over 50, vegetarians, and people taking metformin face higher B12 deficiency risks and should request testing during any anxiety evaluation

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Therapeutic doses are higher than regular doses and help quickly fill up B12 stores in the body

B12 deficiency improvement varieshaematological symptoms may improve within weeks, whilst neurological recovery can take months and may be incomplete if treatment is delayed