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the human relevance is undetermined

1c,d) which catabolize 25(OH)VD 3 and active 1,25(OH) 2 D 3

Tirzepatide may not be suitable for individuals with a history of certain endocrine conditions, thyroid tumors, or other contraindications identified during medical review

Across all GLP-1 medications, 12-month persistence (still taking the medication at one year) ranges from 38% to 56% depending on the study and population (Wilding et al., Diabetes Obes Metab 2023)