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However, it is important to recognise that the overall incidence appears relatively lowmost people taking B12 supplements do not develop acne, though the exact frequency is unknown

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Intramuscular injection represents another option, particularly for deeper tissue injuries or when patients prefer less frequent administration

[10] [11] Intramuscular B12 injections (hydroxocobalamin or cyanocobalamin) bypass the digestive system, but UK product information (SmPCs) for hydroxocobalamin injections does list gastrointestinal disturbances, including diarrhoea, as possible adverse reactions, albeit rare