Polyfunctional thiols refer to thiols that also have other functional groups such as alcohol, ketone or acids
There are also diabetic agents that belong to the class of GLP-1 and Amylin analogues, and these need to be excluded
More importantly, through multi-omics analysis, we found that AA-CDs can specifically target HSPA5, thereby inhibiting the degradation of GPX4
Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C
Despite the limitations associated with identifying bona fide protein-protein interactions by coupling co-immunoprecipitation or proximity labeling with LC/MS-MS, we were able to confidently generate a shorter, more manageable list of 19 potential interacting kinases, predominantly intestinal, for further study