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Long-term therapeutic benefits were also evident

In September 2025, the Food and Drug Administration issued over 50 Warning Letters to companies for marketing compounded GLPs as generic versions or that make comparative claims to FDA-approved versions

Yes, especially for people who dont absorb B12 well due to digestive issues, genetic variations (like MTHFR), or medications such as metformin or acid blockers

10.1038/nature09410 Nature 91 LeeJ