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It has been reported that aberrant expression of the lipid metabolism differential gene CYP19A1 in CRC is not only a prognostic risk factor for CRC patients but also enhances the ability of activated CD8 + T cells to kill CRC cells by suppressing the expression of PD-L1 in CRC cells [50]

& Lundquist, I

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Recently, a potent inhibitor of SLC1A5, V-9302, has been reported to be effective in several cancer cell lines and in vivo tumor models 205

Hence, as part of the defense against the ROS, organisms developed an intricate network of antioxidants that inhibits the oxidation of other molecules by terminating the reactions leading to the production of free radicals