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doi: 10.1345/aph.10022 57 BuneviciusRJakubonieneNJurkeviciusRCernicatJLasasLPrangeAJJ

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In the kidneys of STZ-induced diabetic mice and HK-2 cells cultured with high glucose, iron overload, decreased antioxidant capacity and high rates of ROS production and lipid peroxidation are the signature changes of ferroptosis [225, 228]

To achieve the maximum therapeutic effectiveness, rheumatologists recommend using combination therapy for RA patients (13, 14)