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5 Potential therapeutic targets Up to now, clinical studies targeting SCFAs to improve NAFLD are scarce, and the direction of drug development is mostly based on the promotion of SCFA-producing advantageous microbiota, such as increasing the abundance of Bacteroidetes, Ackermannia, Bifidobacterium, Lactobacillus , and Prevotella , and decreasing the ratios of Firmicutes and F/B (Castillo et al., 2021)

Research in the Journal of Biological Chemistry demonstrated that the probiotic VSL#3 promotes GLP-1 release from intestinal L-cells via butyrate, a short-chain fatty acid produced when gut bacteria ferment fiber