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Wegovy and other GLP-1 receptor agonists have been associated with modest increases in resting heart rate (approximately 2-3 beats per minute on average according to the SmPC, though some individuals may experience larger increases)

PMID: 152 ZhouY.GilmoreK.RamirezS.SettelsE.GammeltoftK

Stress and cortisol According to a systematic review of human trials, amongst many different supplements, Ashwagandha has the most profound effect on hypothalamic-pituitary-adrenal (HPA) axis

Additionally, MK-677 enhances sleep architecture by extending slow-wave sleep phases, which represents the deepest stage of rest