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Who should not use it Its not the right choice for patients with: active cancer or a cancer history (stimulating cell growth signals can be harmful in these cases) active autoimmune conditions, where anything that affects the immune system carries additional risk pregnancy or breastfeeding significantly compromised liver or kidney function These arent minor caveats

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Few other studies in the literature also have reported significant color changes over a period of time

Additionally, preliminary studies are indicating that the risk of major depressive disorder in a patient with a MTHFR mutation is even greater when coupled with other environmental factors such as trauma, diet, and stress