Key Takeaways On April 1, 2026, FDA issued a statement reminding 503A pharmacies and 503B outsourcing facilities that compounded drugs qualify for the statutory exemptions under the Federal Food, Drug, and Cosmetic Act (FD&C Act), only when applicable conditions are satisfied, with specific focus on the essentially a copy standard
Furthermore, administering certain microbial metabolites to mice, such as urolithin A, can enhance barrier function by upregulating AhR and nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent signaling 98
The main targets in these models are thyroid follicular cells, immune cells (particularly T lymphocytes), and the autoantibodies that bind to thyroid antigens
Its presence in gut secretory cells and the pancreas, where it co-localizes with glucagon, suggests potential involvement in metabolic regulation and gastrointestinal function
10.1038/nature05378 66 RochetteL.DogonG.RigalE.ZellerM.CottinY.VergelyC