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Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels

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Glucagon receptor agonism: This third arm drives: Hepatic fat oxidation: Glucagon signals hepatocytes to mobilise stored triglycerides for beta-oxidation, directly addressing non-alcoholic fatty liver disease (NAFLD) pathology

Support for Mitochondrial Energy Production : Through its influence on lipid metabolism, AOD-9604 indirectly enhances mitochondrial ATP generation by increasing the availability of fatty acids as substrates for oxidation