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Its not a war of oral GLP-1 molecules This September, The New England Journal of Medicine published two major phase 3 trials on oral treatments for obesity: Orforglipron (ATTAIN-1, 3,127 participants, 72 weeks) Mean weight loss: 11.2% at 36 mg 10% weight loss: 54.6% of patients Cardiometabolic improvements (waist, BP, lipids) Safety: frequent GI adverse events, 5 mild pancreatitis cases, modest in heart rate Orforglipron (ATTAIN-1, NEJM): Oral Semaglutide 25 mg (OASIS-4, 307 participants, 64 weeks) Mean weight loss: 13.6% 10% weight loss: 63% of patients Cardiometabolic improvements (HbA1c, triglycerides, inflammation) Safety: GI profile consistent with GLP-1 class, some mild dysesthesia Oral semaglutide 25 mg (OASIS-4, NEJM): What they share Adults with obesity, without diabetes, average BMI ~37, 3545% with prediabetes Clinically relevant weight loss vs placebo Typical GLP-1 GI side-effect profile Key differences Scale & diversity: ATTAIN-1 large, multinational

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The Phase 2 data are published and publicly available

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