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The triple agonist mechanism targets GLP-1, GIP, and glucagon receptors simultaneously, creating appetite suppression and metabolic enhancement that single-receptor medications cannot match

As a class effect shared with GLP-1 receptor agonists, there is a precautionary concern regarding thyroid C-cell tumours, based on animal studies

3 Age is also an important risk factor for T2D

Of further interest, the 7 newly formed interfacial salt bridges constitutes a structural electrostatic scaffold (Figures 6, 7, 8, 9, 10 and 11) at the binding interface of GLP-1R ECD and semaglutide analogue A747, which consists of three sets of interfacial salt bridges, as shown by three red numbers (1, 2 and 3) within black circles in Figures 9, 10 and 11

Semaglutide: GLP-1liraglutide(Saxenda)Semaglutide(Wegovy)12 (1218BMI30kg/m2)60kg 3.0mg12 (BMI)4% 2.4 mg 12 (BMI) 5% 2023 GLP-112 611Liraglutide20249NEJM 5646%BMI5.8%1.6%P 27 GLP-1 GLP-1 A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity N Engl J Med 2020