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However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria

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Journal of Biochemistry

Cueto-Urea C, Ramrez-Expsito MJ, Mayas MD, Carrera-Gonzlez MP, Godoy-Hurtado A, Martnez-Martos JM (2023) Glutathione peroxidase gpx1 to gpx8 genes expression in experimental brain tumors reveals gender-dependent patterns