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Malonyl-CoA also plays a vital role in PUFA synthesis, where dietary linoleic acid undergoes sequential desaturation and elongation reactions catalyzed by fatty acid desaturase (FADS)2, ELOVL5 and FADS1, leading to the formation of AA (C20:4, -6), which can be further elongated by ELOVL2/4 to generate AdA (C22:4, -6) (76)
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On the other, ISE directly downregulates the expression of v3 receptors in endothelial cells, blocking the binding of vWF to v3, thereby inhibiting the phosphorylation activation of the FAK/Src pathway
Journal of Alternative and Complementary Medicine (New York, N.Y.), 15 (4), 431433