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There is also a possibility that it is related to variability in absorption
Cold Spring Harb Perspect Biol 11(9):a033886 Kim T, Croce CM (2021) MicroRNA and ER stress in cancer
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While the number of blockbusters (asset-indications forecast to achieve peak sales greater than $1 billion) has decreased to 108 in 2025, down from 111 in 2024, the number of mega-blockbusters (asset-indications forecasts to achieve peak sales greater than $10 billion) has increased from six in 2024 to eight in 2025
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