doi: 10.3389/fnins.2021.630016 Received 16 November 2020 Accepted 20 January 2021 Published 05 February 2021 Volume 15 - 2021 Edited by Matthew William Pitts, University of Hawaii at Mnoa, United States Reviewed by Frederick P
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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
