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The risks associated with these medications muscle loss, malnutrition, and digestive issues dont develop overnight

Ann Rev Neurosci 25 : 151188

And it supports bone health, which prevents one of the most common forms of collateral damage during aggressive weight loss

Supports metabolism and helps maintain healthy blood lipids

Recently, through the engagement of their respective receptors, studies have shown that GIP and GLP-1 have a synergistic effect on appetite and body weight when the peptides are combined in pharmacology [6, 8], but the exact mechanisms underlying the enhanced weight loss exhibited by GIPR/GLP-1R co-agonism are still to be elucidated