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Journal of the American Society of Nephrology [Internet]

In the Phase 2 trial published in the New England Journal of Medicine, participants receiving the highest dose of retatrutide (12mg weekly) achieved a mean body weight reduction of 24.2% over 48 weeks

Combinations with other peptides have not been formally studied in published clinical research

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A: Tirzepatide mimics the effects of natural hormones (including GLP-1) that help control blood sugar and signal fullness to the brain