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Activation of the MC1 receptor promotes skin pigmentation, while activation of the MC4 receptor can enhance tendency to penile erection

Comparison of the exendin-4 and exendin-P5 bound (PDB 6B3J) structures revealed similarities in their ECD location and greater similarities of the backbone orientations for TMs 1-5, relative to the GLP-1- and oxyntomodulin-bound complexes (Figure 3)