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GSH works as an antioxidant, and GSH deficiency has been reported in several central nervous system (CNS) disorders, including multiple sclerosis, Alzheimers, autism, and bipolar disease, as well as PD

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In humans, a systematic review and meta-analysis revealed that physiologically high selenium levels in the body were negatively associated with cardiovascular disease morbidity and mortality

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This then consumes glutathione for its conjugation, resulting in depletion of glutathione stores