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When You Might Need Higher B12 Doses While the standard RNI of 1.5 mcg per day suffices for most healthy adults, certain medical conditions, dietary patterns, and medications can substantially increase B12 requirements or impair absorption, necessitating higher therapeutic doses under medical supervision

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Bone Density: Mouse model studies have also linked IGF-1 signaling to improvements in bone density and skeletal strength, suggesting systemic health benefits beyond just muscular development